| Elemental Essence Shard (Air) | SCF | rare | by a sorcerer | TCE |
| Elemental Essence Shard (Earth) | SCF | rare | by a sorcerer | TCE |
| Elemental Essence Shard (Fire) | SCF | rare | by a sorcerer | TCE |
| Elemental Essence Shard (Water) | SCF | rare | by a sorcerer | TCE |
| Elemental Gem, Blue Sapphire | — | uncommon | — | DMG |
| Elemental Gem, Blue Sapphire | — | uncommon | — | XDMG |
| Elemental Gem, Emerald | — | uncommon | — | DMG |
| Elemental Gem, Emerald | — | uncommon | — | XDMG |
| Elemental Gem, Red Corundum | — | uncommon | — | DMG |
| Elemental Gem, Red Corundum | — | uncommon | — | XDMG |
| Elemental Gem, Yellow Diamond | — | uncommon | — | DMG |
| Elemental Gem, Yellow Diamond | — | uncommon | — | XDMG |
| Elephant | MNT | none | — | PHB |
| Elephant | MNT|XPHB | none | — | XPHB |
| Elixir of Health | P | rare | — | DMG |
| Elixir of Health | P|XPHB | rare | — | XDMG |
| Elven Chain | MA | rare | — | DMG |
| Elven Thrower | M | very rare | by a elf | BGG |
| Elven Trinket | G | none | — | MTF |
| Emblem | SCF | none | — | PHB |
| Emblem | SCF|XPHB | none | — | XPHB |
| Embroidered glove set with jewel chips | $A|DMG | none | — | DMG |
| Embroidered glove set with jewel chips | $A|XDMG | none | — | XDMG |
| Embroidered silk and velvet mantle set with numerous moonstones | $A|DMG | none | — | DMG |
| Embroidered silk and velvet mantle set with numerous moonstones | $A|XDMG | none | — | XDMG |
| Embroidered silk handkerchief | $A|DMG | none | — | DMG |
| Embroidered silk handkerchief | $A|XDMG | none | — | XDMG |
| Emerald | $G|DMG | none | — | DMG |
| Emerald | $G|XDMG | none | — | XDMG |
| Emerald Enclave Trinket | G|XPHB | none | — | FRHoF |
| Emerald Pen | — | uncommon | — | FTD |
| Enchanted Three-Dragon Ante Set | — | — | — | LLK |
| Enduring Spellbook | — | common | — | XDMG |
| Enduring Spellbook | — | common | — | XGE |
| Enspelled Staff (Cantrip) | M|XPHB | uncommon | by a Spellcaster | XDMG |
| Enspelled Staff (Level 1) | M|XPHB | uncommon | by a Spellcaster | XDMG |
| Enspelled Staff (Level 2) | M|XPHB | rare | by a Spellcaster | XDMG |
| Enspelled Staff (Level 3) | M|XPHB | rare | by a Spellcaster | XDMG |
| Enspelled Staff (Level 4) | M|XPHB | very rare | by a Spellcaster | XDMG |
| Enspelled Staff (Level 5) | M|XPHB | very rare | by a Spellcaster | XDMG |
| Enspelled Staff (Level 6) | M|XPHB | legendary | by a Spellcaster | XDMG |
| Enspelled Staff (Level 7) | M|XPHB | legendary | by a Spellcaster | XDMG |
| Enspelled Staff (Level 8) | M|XPHB | legendary | by a Spellcaster | XDMG |
| Entertainer's Pack | G | none | — | PHB |
| Entertainer's Pack | G|XPHB | none | — | XPHB |
| Ephixis, Bow of Nylea | R | artifact | Yes | MOT |
| Ersatz Eye | — | common | — | XDMG |
| Ersatz Eye | — | common | — | XGE |
| Essence of Ether | G | none | — | DMG |
| Essence of Ether | G|XPHB | none | — | XDMG |
