| Spell Scroll (Level 9) | SC|XPHB | legendary | — | XDMG |
| Spell-Refueling Ring | RG|XDMG | uncommon | by a spellcaster | EFA |
| Spellbook | G | none | — | PHB |
| Spellguard Shield | S | very rare | Yes | DMG |
| Spellguard Shield | S|XPHB | very rare | Yes | XDMG |
| Spelljamming Helm | — | rare | by a spellcaster | AAG |
| Spellshard | — | common | — | ERLW |
| Spellwrought Tattoo (1st Level) | — | common | — | TCE |
| Spellwrought Tattoo (2nd Level) | — | uncommon | — | TCE |
| Spellwrought Tattoo (3rd Level) | — | uncommon | — | TCE |
| Spellwrought Tattoo (4th Level) | — | rare | — | TCE |
| Spellwrought Tattoo (5th Level) | — | rare | — | TCE |
| Spellwrought Tattoo (Cantrip) | — | common | — | TCE |
| Sphere of Annihilation | — | legendary | — | DMG |
| Sphere of Annihilation | — | legendary | — | XDMG |
| Spider Staff | — | rare | Yes | LMoP |
| Spider Staff | M | rare | by a bard, sorcerer, warlock, or wizard | PaBTSO |
| Spies' Murmur | — | uncommon | Yes | GGR |
| Spiked Shield | S|XPHB | uncommon | Yes | WttHC |
| Spindle of Fate | WD|DMG | legendary | Yes | BMT |
| Spinel | $G|DMG | none | — | DMG |
| Spinel | $G|XDMG | none | — | XDMG |
| Spirit Board | — | very rare | — | XDMG |
| Sprig of Mistletoe | SCF | none | — | PHB |
| Sprig of Mistletoe | SCF|XPHB | none | — | XPHB |
| Spyglass | G | none | — | PHB |
| Spyglass | G|XPHB | none | — | XPHB |
| Spyglass of Clairvoyance | — | common | — | AI |
| Squid Ship | SPC|AAG | none | — | AAG |
| Stabling (per day) | TAH | none | — | PHB |
| Stabling (per day) | TAH|XPHB | none | — | XPHB |
| Staff of Adornment | M|XPHB | common | — | XDMG |
| Staff of Adornment | — | common | — | XGE |
| Staff of Birdcalls | M|XPHB | common | — | XDMG |
| Staff of Birdcalls | — | common | — | XGE |
| Staff of Charming | — | rare | by a bard, cleric, druid, sorcerer, warlock, or wizard | DMG |
| Staff of Charming | M|XPHB | rare | by a bard, cleric, druid, sorcerer, warlock, or wizard | XDMG |
| Staff of Defense | — | rare | Yes | LMoP |
| Staff of Defense | M | rare | by a bard, sorcerer, warlock, or wizard | PaBTSO |
| Staff of Dunamancy | — | very rare | by a wizard | EGW |
| Staff of Fate | M | very rare | Yes | CM |
| Staff of Fire | — | very rare | by a druid, sorcerer, warlock, or wizard | DMG |
| Staff of Fire | M|XPHB | very rare | by a druid, sorcerer, warlock, or wizard | XDMG |
| Staff of Flowers | M|XPHB | common | — | XDMG |
| Staff of Flowers | — | common | — | XGE |
| Staff of Frost | — | very rare | by a druid, sorcerer, warlock, or wizard | DMG |
| Staff of Frost | M|XPHB | very rare | by a druid, sorcerer, warlock, or wizard | XDMG |
| Staff of Healing | — | rare | by a bard, cleric, or druid | DMG |
| Staff of Healing | M|XPHB | rare | by a bard, cleric, or druid | XDMG |
| Staff of Power | — | very rare | by a sorcerer, warlock, or wizard | DMG |
